ArticleDiarrheal diseases

Université nationale d'Asuncion (Instituto de Investigaciones en Ciencias de la Salud)

Genomic characterization of a rotavirus G8P[1] detected in a child with diarrhea reveal direct animal-to-human transmission

Magaly Martinez, Tung Gia Phan, Maria Eugenia Galeano, Graciela RUSSOMANDO, Viviana Parreno, Eric Delwart, Gabriel I. Parra

Infect Genet Evol. 2014 Aug 25. pii: S1567-1348(14)00303-7


Group A rotavirus is a major cause of severe gastroenteritis in children and young animals. During a retrospective analysis of samples collected from Paraguayan children under 5 years old with diarrhea, and previously negative for rotavirus and norovirus, we detected the presence of bovine rotavirus sequences by viral metagenomics. Nucleic acid was extracted direct from stool sample and determined to be G8P[1]. The genomic analyzes revealed that the strain presents an Artiodactyl-like genome (G8-P[1]-I2-R2-C2-M1-Ax-N2-T6-E12-H3) suggesting a direct animal-to-human transmission.

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