Efficacy of nitazoxanide against clinical isolates of Mycobacterium Tuberculosis

Shigyo K, Ocheretina O, Merveille YM, Johnson WD, Pape JW, Nathan CF, Fitzgerald DW

Antimicrob Agents Chemother. 2013 Mar 18. [Epub ahead of print]


Nitazoxanide (NTZ) has bactericidal activity against the H37Rv laboratory strain of Mycobacterium tuberculosis (Mtb) with a minimum inhibitory concentration (MIC) of 16 μg/mL. However, its efficacy against clinical isolates of Mtb has not been determined. We found that NTZ’s MIC against 50 clinical isolates ranged from 12-28 μg/mL with a median of 16 μg/mL and was unaffected by resistance to first or second line anti-tuberculosis drugs or a diversity of spoligotypes.

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