ArticleHIV

Rodolphe Mérieux Laboratory of Haiti

Clinical and virologic outcomes after changes in first antiretroviral regimen at 7 sites in the Caribbean, Central and South America network

Wolff M, Shepherd BE, Cortes C, Rebeiro P, Cesar C, Wagner Cardoso S, Pape JW, Padgett D, Sierra-Madero J, Echevarria J, McGowan CC; Caribbean, Central and South America Network for HIV Epidemiology (CCASAnet)

J Acquir Immune Defic Syndr. 2016 Jan 1;71(1):102-10

Abstract

Background:

HIV-infected persons in resource-limited settings may experience high rates of antiretroviral therapy (ART) change, particularly because of toxicity or other nonfailure reasons. Few reports address patient outcomes after these modifications.

Methods:

HIV-infected adults from the 7 Caribbean, Central and South America network clinical cohorts who modified >1 drug from the first ART regimen (ART-1) for any reason thereby starting a second regimen (ART-2) were included. We assessed cumulative incidence of, and factors associated with, death, virologic failure (VF), and regimen change after starting ART-2.

Results:

Conclusions:

Among patients modifying the first ART regimen, risks of subsequent modifications, mortality, and virologic failure were high. Access to improved antiretrovirals in the region is needed to improve initial treatment success.

PubMed website